Development of the clinical candidate PBD-C06, a humanized pGlu3-Aβ-specific antibody against Alzheimer’s disease with reduced complement activation

Abstract In clinical trials with early Alzheimer’s patients, administration of anti-amyloid antibodies reduced amyloid deposits, suggesting that immunotherapies may be promising disease-modifying interventions against Alzheimer’s disease (AD). Specific forms of amyloid beta (Aβ) peptides, for exampl...

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Bibliografiske detaljer

Principais autores:	Thore Hettmann, Stephen D. Gillies, Martin Kleinschmidt, Anke Piechotta, Koki Makioka, Cynthia A. Lemere, Stephan Schilling, Jens-Ulrich Rahfeld, Inge Lues
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2020-02-01
Serier:	Scientific Reports
Online adgang:	https://doi.org/10.1038/s41598-020-60319-5
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