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mTOR hypoactivity leads to trophectoderm cell failure by enhancing lysosomal activation and disrupting the cytoskeleton in preimplantation embryo

Abstract Background Metabolic homeostasis is closely related to early impairment of cell fate determination and embryo development. The protein kinase mechanistic target of rapamycin (mTOR) is a key regulator of cellular metabolism in the body. Inhibition of mTOR signaling in early embryo causes pos...

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Kaydedildi:
Asıl Yazarlar: Chiyuan Ma, Qin Li, Yuxin Yang, Lei Ge, Jiaxuan Cai, Juan Wang, Maoxian Zhu, Yue Xiong, Wenya Zhang, Jingtong Xie, Yujing Cao, Huashan Zhao, Qing Wei, Chen Huang, Junchao Shi, Jian V. Zhang, Enkui Duan, Xiaohua Lei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMC 2023-11-01
Seri Bilgileri:Cell & Bioscience
Konular:
mTOR
Trophectoderm cell failure
Transcriptome
DNA methylation
Lysosomal activation
Actin cytoskeleton disruption
Online Erişim:https://doi.org/10.1186/s13578-023-01176-3
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