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2’-5’ Oligoadenylate Synthetase-Like 1- (OASL1-) deficient mice promote antiviral protection against pseudorabies virus infection associated with enhanced production of type I interferon

Abstract Pseudorabies virus (PRV) infects various mammals and causes Aujeszky’s disease, posing a significant threat to the pig industry. The interaction between PRV and the host’s innate immune system, however, remains poorly understood. The interferon (IFN)-stimulated gene (ISG), 2’-5’ oligoadenyl...

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Principais autores: Tien Huyen Ton Nu Bao, Mwense Leya, Thach Phan Van, Gaeul Ham, ByungKwan Oh, Sang-Ik Oh, Won-Il Kim, Seok-Chan Park, Bumseok Kim
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2026-03-01
Serier:Scientific Reports
Fag:
PRV
OASL1
Type I IFNs
IRF7
Mice
Online adgang:https://doi.org/10.1038/s41598-026-43144-0
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