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The xenobiotic transporter ABCC4/MRP4 promotes epithelial mesenchymal transition in pancreatic cancer

The xenobiotic transporter ABCC4/MRP4 is highly expressed in pancreatic ductal adenocarcinoma (PDAC) and correlates with a more aggressive phenotype and metastatic propensity. Here, we show that ABCC4 promotes epithelial-mesenchymal transition (EMT) in PDAC, a hallmark process involving the acquisit...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: S. N. Gancedo, A. Sahores, N. Gómez, N. Di Siervi, M. May, A. Yaneff, M. G. de Sousa Serro, N. Fraunhoffer, N. Dusetti, J. Iovanna, C. Shayo, C. A. Davio, B. González
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Frontiers Media S.A. 2024-07-01
Rangatū:Frontiers in Pharmacology
Ngā marau:
PDAC
ABCC4/MRP4
epithelial mesenchymal transition
prognosis marker
FOXA1 GATA2
Urunga tuihono:https://www.frontiersin.org/articles/10.3389/fphar.2024.1432851/full
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