Co-expression of Skp and FkpA chaperones improves cell viability and alters the global expression of stress response genes during scFvD1.3 production
<p>Abstract</p> <p>Background</p> <p>The overexpression of scFv antibody fragments in the periplasmic space of <it>Escherichia coli </it>frequently results in extensive protein misfolding and loss of cell viability. Although protein folding factors such as Skp and FkpA are often exploited to restore...
Kaydedildi:
| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
BMC
2010-04-01
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| Seri Bilgileri: | Microbial Cell Factories |
| Online Erişim: | http://www.microbialcellfactories.com/content/9/1/22 |
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