Rapamycin-induced hyperglycemia is associated with exacerbated age-related osteoarthritis

Abstract Background The objective of this study was to determine if mechanistic target of rapamycin (mTOR) inhibition with or without AMP-activated protein kinase (AMPK) activation can protect against primary, age-related OA. Design Dunkin-Hartley guinea pigs develop mild primary OA pathology by 5 m...

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Detalhes bibliográficos

Principais autores:	Dennis M. Minton, Christian J. Elliehausen, Martin A. Javors, Kelly S. Santangello, Adam R. Konopka
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2021-10-01
coleção:	Arthritis Research & Therapy
Assuntos:	Aging mTOR AMPK Dunkin Hartley guinea pig Primary osteoarthritis
Acesso em linha:	https://doi.org/10.1186/s13075-021-02637-1
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