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BET Protein Inhibitor JQ1 Modulates Mitochondrial Dysfunction and Oxidative Stress Induced by Chronic Kidney Disease

Among the mechanisms involved in the progression of kidney disease, mitochondrial dysfunction has special relevance. Epigenetic drugs such as inhibitors of extra-terminal domain proteins (iBET) have shown beneficial effects in experimental kidney disease, mainly by inhibiting proliferative and infla...

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Main Authors: Sandra Rayego-Mateos, Pamela Basantes, José Luis Morgado-Pascual, Beatriz Brazal Prieto, Beatriz Suarez-Alvarez, Alberto Ortiz, Carlos Lopez-Larrea, Marta Ruiz-Ortega
Format: Artigo
Language:Inglês
Published: MDPI AG 2023-05-01
Series:Antioxidants
Subjects:
mitochondrial dysfunction
BET proteins
JQ1
renal damage
mitochondrial dynamics
mitophagy
Online Access:https://www.mdpi.com/2076-3921/12/5/1130
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