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Circulating metabolite signatures indicate differential gut-liver crosstalk in lean and obese MASLD

BACKGROUND Alterations in circulating metabolites have been described in obese metabolic dysfunction–associated steatotic liver disease (MASLD), but data on lean MASLD are lacking. We investigated serum metabolites, including microbial bile acids and short-chain fatty acids (SCFAs), and their associ...

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Tallennettuna:
Päätekijät: Mathias Haag, Stefan Winter, Aurino M. Kemas, Julia Tevini, Alexandra Feldman, Sebastian K. Eder, Thomas K. Felder, Christian Datz, Bernhard Paulweber, Gerhard Liebisch, Oliver Burk, Volker M. Lauschke, Elmar Aigner, Matthias Schwab
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical investigation 2025-04-01
Sarja:JCI Insight
Aiheet:
Hepatology
Metabolism
Linkit:https://doi.org/10.1172/jci.insight.180943
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