Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction

A versatile continuous-flow synthesis of highly functionalized 1,2,4-oxadiazoles starting from carboxylic acids is reported. This process was applied to the multistep synthesis of imidazo[1,2-a]pyridin-2-yl-1,2,4-oxadiazoles, using a three reactor, multistep continuous-flow system without isolation...

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Bibliographic Details

Main Authors:	Ananda Herath, Nicholas D. P. Cosford
Format:	Artigo
Language:	Inglês
Published:	Beilstein-Institut 2017-02-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	imidazo[1,2-a]pyridine imidazo[1,2-a]pyridin-2-yl-1,2,4-oxadiazole liquid–liquid extraction module microreactor 1,2,4-oxadiazole
Online Access:	https://doi.org/10.3762/bjoc.13.26
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