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Tumor matrix stiffness provides fertile soil for cancer stem cells

Abstract Matrix stiffness is a mechanical characteristic of the extracellular matrix (ECM) that increases from the tumor core to the tumor periphery in a gradient pattern in a variety of solid tumors and can promote proliferation, invasion, metastasis, drug resistance, and recurrence. Cancer stem ce...

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Principais autores: Sadegh Safaei, Roya Sajed, Ahmad Shariftabrizi, Shima Dorafshan, Leili Saeednejad Zanjani, Masoumeh Dehghan Manshadi, Zahra Madjd, Roya Ghods
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2023-07-01
Series:Cancer Cell International
Assuntos:
Extracellular matrix (ECM)
Matrix Stiffness
Mechanotransduction
Cancer stem cells (CSC)
Metastasis
Chemoresistance
Acceso en liña:https://doi.org/10.1186/s12935-023-02992-w
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