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Temporally discordant chromatin accessibility and DNA demethylation define short- and long-term enhancer regulation during cell fate specification

Summary: Chromatin and DNA modifications mediate the transcriptional activity of lineage-specifying enhancers, but recent work challenges the dogma that joint chromatin accessibility and DNA demethylation are prerequisites for transcription. To understand this paradox, we established a highly resolv...

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Principais autores: Lindsey N. Guerin, Timothy J. Scott, Jacqueline A. Yap, Annelie Johansson, Fabio Puddu, Tom Charlesworth, Yilin Yang, Alan J. Simmons, Ken S. Lau, Rebecca A. Ihrie, Emily Hodges
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-05-01
Serier:Cell Reports
Fag:
CP: Molecular biology
CP: Developmental biology
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124725004516
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