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The Core Splicing Factors EFTUD2, SNRPB and TXNL4A Are Essential for Neural Crest and Craniofacial Development

Mandibulofacial dysostosis (MFD) is a human congenital disorder characterized by hypoplastic neural-crest-derived craniofacial bones often associated with outer and middle ear defects. There is growing evidence that mutations in components of the spliceosome are a major cause for MFD. Genetic varian...

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Principais autores: Byung-Yong Park, Melanie Tachi-Duprat, Chibuike Ihewulezi, Arun Devotta, Jean-Pierre Saint-Jeannet
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-07-01
Serier:Journal of Developmental Biology
Fag:
<i>Xenopus</i>
neural crest
craniofacial
mandibulofacial dysostosis
apoptosis
spliceosome
Online adgang:https://www.mdpi.com/2221-3759/10/3/29
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