Human cytomegalovirus UL18 utilizes US6 for evading the NK and T-cell responses.
Human cytomegalovirus (HCMV) US6 glycoprotein inhibits TAP function, resulting in down-regulation of MHC class I molecules at the cell surface. Cells lacking MHC class I molecules are susceptible to NK cell lysis. HCMV expresses UL18, a MHC class I homolog that functions as a surrogate to prevent ho...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science (PLoS)
2008-01-01
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| Series: | PLoS Pathogens |
| Acceso en liña: | http://europepmc.org/articles/PMC2483941?pdf=render |
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