Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential

Abstract Background Human mitochondrial DNA mutations are associated with common to rare mitochondrial disorders, which are multisystemic with complex clinical pathologies. The pathologies of these diseases are poorly understood and have no FDA-approved treatments leading to symptom management. Leig...

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Principais autores:	Fibi Meshrkey, Kelly M. Scheulin, Christopher M. Littlejohn, Joshua Stabach, Bibhuti Saikia, Vedant Thorat, Yimin Huang, Thomas LaFramboise, Edward J. Lesnefsky, Raj R. Rao, Franklin D. West, Shilpa Iyer
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2023-11-01
Series:	Stem Cell Research & Therapy
Assuntos:	Mitochondrial disease hiPSC Pluripotent stem cell Reprogramming Bioenergetics Respiration
Acceso en liña:	https://doi.org/10.1186/s13287-023-03546-7
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