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Targeting RuvBL1 disrupts mitochondrial metabolism and structure in hepatocellular carcinoma

Background & Aims: The AAA+ ATPase RuvBL1 takes part in several biological processes, including chromatin remodelling and DNA repair, ribosome biogenesis, mTOR signalling, and oncogenic transformation. RUVBL1 overexpression correlates with poor survival in patients with hepatocellular carcinoma...

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Furkejuvvon:
Váldodahkkit: Tommaso Mello, Irene Simeone, Alice Guida, Dimitri Papini, Francesca Begnozzi, Alice Santi, Daniele Guasti, Patrizia Nardini, Simone Polvani, Matteo Lulli, Oxana Bereshchenko, Elisabetta Ceni, Armando Curto, Paolo Pinton, Massimo Bonora, Andrea Galli
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Elsevier 2026-07-01
Ráidu:JHEP Reports
Fáttát:
OXPHOS
ATP synthase
TCA cycle
Amino acids metabolism
Ketogenesis
Liver cancer
Liŋkkat:http://www.sciencedirect.com/science/article/pii/S2589555926001291
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