Response to primary chemoradiotherapy of locally advanced oropharyngeal carcinoma is determined by the degree of cytotoxic T cell infiltration within tumor cell aggregates

BackgroundEffective anti-tumor immune responses are mediated by T cells and require organized, spatially coordinated interactions within the tumor microenvironment (TME). Understanding coordinated T-cell-behavior and deciphering mechanisms of radiotherapy resistance mediated by tumor stem cells will...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Maximilian Haist, Justus Kaufmann, Ivan-Maximiliano Kur, Stefanie Zimmer, Stephan Grabbe, Heinz Schmidberger, Andreas Weigert, Arnulf Mayer
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2023-04-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	head-and-neck cancer oropharyngeal squamous cell carcinoma spatial tumor biology multiplex immunohistochemistry CD8 T cells tumor microenvironment
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1070203/full
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