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Mesenchymal stem cell conditioned medium increases glial reactivity and decreases neuronal survival in spinal cord slice cultures

Ex vivo spinal cord slice cultures (SCSC) allow study of spinal cord circuitry, maintaining stimuli responses comparable to live animals. Previously, we have shown that mesenchymal stem/stromal cell (MSC) transplantation in vivo reduced inflammation and increased nerve regeneration but MSC survival...

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Principais autores: Chelsea R. Wood, Esri H. Juárez, Francesco Ferrini, Peter Myint, John Innes, Laura Lossi, Adalberto Merighi, William E.B. Johnson
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021-07-01
Serier:Biochemistry and Biophysics Reports
Fag:
Mesenchymal stem/stromal cell
Spinal cord slice cultures
Astrocyte hypertrophy
Neuronal survival
Calcium imaging
Online adgang:http://www.sciencedirect.com/science/article/pii/S2405580821000704
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