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Consequences and Resolution of Transcription–Replication Conflicts

Transcription–replication conflicts occur when the two critical cellular machineries responsible for gene expression and genome duplication collide with each other on the same genomic location. Although both prokaryotic and eukaryotic cells have evolved multiple mechanisms to coordinate these proces...

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Autori principali: Maxime Lalonde, Manuel Trauner, Marcel Werner, Stephan Hamperl
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2021-06-01
Serie:Life
Soggetti:
transcription–replication conflicts
genomic instability
R-loops
torsional stress
common fragile sites
early replicating fragile sites
Accesso online:https://www.mdpi.com/2075-1729/11/7/637
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