SCAN-ACT: adoptive T cell therapy target discovery through single-cell transcriptomics

Abstract Background The FDA approval of T cell receptor-engineered T cells (TCR-T) for synovial sarcoma demonstrates the potential for adoptive T cell therapies (ACTs) in solid tumors. However, the paucity of tumor-associated targets without expression in normal tissues remains a major bottleneck, e...

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Autores principales:	Stefano Testa, Aastha Pal, Ajay Subramanian, Sushama Varma, Jack Pengfei Tang, Danielle Graham, Sara Arfan, Minggui Pan, Nam Q. Bui, Kristen N. Ganjoo, Sarah Dry, Paul Huang, Matt van de Rijn, Wei Jiang, Anusha Kalbasi, Everett J. Moding
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2025-08-01
Colección:	Genome Medicine
Materias:	Cellular therapy CAR-T cells TCR-T cells Peptide-centric CAR-T Logic-gated CAR-T Single-cell RNA sequencing
Acceso en línea:	https://doi.org/10.1186/s13073-025-01514-9
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