Self-amplifying RNA (saRNA) and circular RNA (circRNA) vaccines: Progress, evidence gaps, and translational pathways for durable and scalable immunization

Self-amplifying RNA (saRNA) and circular RNA (circRNA) are emerging vaccine modalities that extend conventional, non-replicating mRNA platforms. Self-amplifying RNA encodes a replicase that amplifies intracellular RNA templates, enabling high antigen expression at substantially lower doses than non-...

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Detalhes bibliográficos

Principais autores:	Ugwu Okechukwu Paul-Chima, Okon Michael Ben, Ogenyi Fabian C., Ugwu Jovita Nnenna, Ugwu Chinyere N.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2026-12-01
Colecção:	Human Vaccines & Immunotherapeutics
Assuntos:	Self-amplifying RNA circular RNA replicon mRNA vaccines lipid nanoparticles durability
Acesso em linha:	https://www.tandfonline.com/doi/10.1080/21645515.2026.2661120
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