131I/MTX-loaded engineered outer membrane vesicles for sequentially coordinated radio-metabolic-immunotherapy of glioma

Abstract The efficacy of radiotherapy for brain tumors is limited by tumor cell radio-resistance and the immunosuppressive microenvironment, which often counteracts the immunogenic effects of radiation-induced antitumor responses. To address this, we developed statherin-enriched engineered outer mem...

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Auteurs principaux:	Maolin Liang, Longfei Fan, Suming Zhang, Hua Chen, Xuexue Dong, Lin Hu, Guanglin Wang, Kai Yang, Pei Pei, Ran Zhu
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2025-12-01
Collection:	Journal of Nanobiotechnology
Sujets:	Engineered OMVs Metabolic interference Radiotherapy Immunotherapy Glioma
Accès en ligne:	https://doi.org/10.1186/s12951-025-03936-4
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