Synthesis, Neuroprotection, and Antioxidant Activity of 1,1′-Biphenylnitrones as α-Phenyl-<i>N-tert</i>-butylnitrone Analogues in In Vitro Ischemia Models

Herein, we report the neuroprotective and antioxidant activity of 1,1′-biphenyl nitrones (<b>BPNs</b>) <b>1</b>–<b>5</b> as α-phenyl-<i>N</i>-<i>tert</i>-butylnitrone analogues prepared from commercially available [1,1′-biphenyl]-4-carbaldehyde and [1,1′-biphenyl]-4,4′-dicarbaldehyde. The neuroprote...

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Autors principals:	Beatriz Chamorro, David García-Vieira, Daniel Diez-Iriepa, Estíbaliz Garagarza, Mourad Chioua, Dimitra Hadjipavlou-Litina, Francisco López-Muñoz, José Marco-Contelles, María Jesús Oset-Gasque
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2021-02-01
Col·lecció:	Molecules
Matèries:	antioxidants 1,1′-biphenyl nitrones free radical scavengers neuroprotection oligomycin A/rotenone oxygen-glucose-deprivation
Accés en línia:	https://www.mdpi.com/1420-3049/26/4/1127
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