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Development of a Cost-Effective HPLC Method for Measuring BACE1 Activity in the Presence of Peptide Inhibitors

Objectives: Using high-performance liquid chromatography (HPLC), we developed and validated an in vitro assay for the quantitative determination of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) activity, supplementing limited current methodologies to assess the efficacy of BACE1 inhi...

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Principais autores: Samuel King, Brock Wright, Cenk Suphioglu
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-03-01
Serier:Analytica
Fag:
Alzheimer’s disease
beta-secretase 1
enzyme inhibitor
peptides
high-performance liquid chromatography
Online adgang:https://www.mdpi.com/2673-4532/7/1/20
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