Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3Kγ-dependent fluid-phase pinocytosis of native LDL[S]

Accumulation of cholesterol by macrophage uptake of LDL is a key event in the formation of atherosclerotic plaques. Previous research has shown that granulocyte-macrophage colony-stimulating factor (GM-CSF) is present in atherosclerotic plaques and promotes aortic lipid accumulation. However, it has...

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Autori principali:	Joshua J. Anzinger, Janet Chang, Qing Xu, Manoj K. Barthwal, Thomas Bohnacker, Matthias P. Wymann, Howard S. Kruth
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2012-01-01
Serie:	Journal of Lipid Research
Soggetti:	atherosclerosis cholesterol granulocyte-macrophage colony-stimulating factor phosphoinositide 3-kinase low density lipoprotein
Accesso online:	http://www.sciencedirect.com/science/article/pii/S0022227520407977
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