A dose‐adjusted, open‐label, pilot study of the safety, tolerability, and pharmacokinetics of STC3141 in critically ill patients with sepsis

Abstract Increased circulating histones correlate with sepsis severity and are a potential therapeutic target. Pre‐clinical studies showed benefit with a histone‐neutralizing polyanion molecule (STC3141). We aimed to investigate the safety, tolerability, and pharmacokinetics of STC3141 in critically...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Rinaldo Bellomo, John Patava, Ruth Van Lancker, Nathalie Layios, Marijke Peetermans, Mark Plummer, Rachid Attou, Robert McNamara, Andrew Udy, Bradley Wibrow, Adam Deane, Edward Litton, Marcel Tanudji, Fuhong Su, Zhang Zhong, Linda Shi, Li Ning
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2024-10-01
Serie:	Pharmacology Research & Perspectives
Soggetti:	histones inflammatory response NETs sepsis small molecule polyanion
Accesso online:	https://doi.org/10.1002/prp2.70015
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!