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Engineering Stem Cell Factor Ligands with Different c-Kit Agonistic Potencies

Receptor tyrosine kinases (RTKs) are major players in signal transduction, regulating cellular activities in both normal regeneration and malignancy. Thus, many RTKs, c-Kit among them, play key roles in the function of both normal and neoplastic cells, and as such constitute attractive targets for t...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Tal Tilayov, Tal Hingaly, Yariv Greenshpan, Shira Cohen, Barak Akabayov, Roi Gazit, Niv Papo
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2020-10-01
Schriftenreihe:Molecules
Schlagworte:
receptor tyrosine kinases
protein-protein interactions
protein engineering
directed evolution
angiogenesis
binding affinity
Online-Zugang:https://www.mdpi.com/1420-3049/25/20/4850
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