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Hepatic MDM2 Causes Metabolic Associated Fatty Liver Disease by Blocking Triglyceride‐VLDL Secretion via ApoB Degradation

Abstract Dysfunctional triglyceride‐very low‐density lipoprotein (TG‐VLDL) metabolism is linked to metabolic‐associated fatty liver disease (MAFLD); however, the underlying cause remains unclear. The study shows that hepatic E3 ubiquitin ligase murine double minute 2 (MDM2) controls MAFLD by blockin...

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Автори: Huige Lin, Lin Wang, Zhuohao Liu, Kekao Long, Mengjie Kong, Dewei Ye, Xi Chen, Kai Wang, Kelvin KL Wu, Mengqi Fan, Erfei Song, Cunchuan Wang, Ruby LC Hoo, Xiaoyan Hui, Philip Hallenborg, Hailong Piao, Aimin Xu, Kenneth KY Cheng
Формат: Artigo
Мова:Inglês
Опубліковано: Wiley 2022-07-01
Серія:Advanced Science
Предмети:
apolipoprotein B (ApoB)
murine double minute 2 (MDM2)
metabolic associated fatty liver
obesity
triglyceride‐VLDL
Онлайн доступ:https://doi.org/10.1002/advs.202200742
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