A study on the genetic polymorphisms of CYP3A5 among the Orang Asli in Malaysia using a next generation sequencing platform

Background: CYP3A5 is the predominant sub-family of biotransformation enzymes in the liver and the genetic variations in CYP3A5 are an important determinant of inter-individual and inter-ethnic differences in CYP3A-mediated drug disposition and response. Aim: This study aims to investigate the genet...

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Autors principals:	Geik Yong Ang, Choo Yee Yu, Richard Johari James, Aminuddin Ahmad, Thuhairah Abdul Rahman, Fadzilah Mohd Nor, Syahrul Azlin Shaari, Adzrool Idzwan Ismail, Lay Kek Teh, Mohd Zaki Salleh
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis Group 2018-02-01
Col·lecció:	Annals of Human Biology
Matèries:	aborigines cytochrome p450 whole genome sequences novel intronic polymorphisms pharmacogenomics
Accés en línia:	http://dx.doi.org/10.1080/03014460.2018.1440004
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