SiRNA-induced mutation in HIV-1 polypurine tract region and its influence on viral fitness.

Converting single-stranded viral RNA into double stranded DNA for integration is an essential step in HIV-1 replication. Initial polymerization of minus-strand DNA is primed from a host derived tRNA, whereas subsequent plus-strand synthesis requires viral primers derived from the 3' and central poly...

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Principais autores:	Jason W Rausch, Meijuan Tian, Yuejin Li, Lora Angelova, Bernard S Bagaya, Kendall C Krebs, Feng Qian, Chuanwu Zhu, Eric J Arts, Stuart F J Le Grice, Yong Gao
Formato:	Artigo
Idioma:	Inglês
Publicado:	Public Library of Science (PLoS) 2015-01-01
Series:	PLoS ONE
Acceso en liña:	http://europepmc.org/articles/PMC4393142?pdf=render
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