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Transgelin promotes lung cancer progression via activation of cancer-associated fibroblasts with enhanced IL-6 release

Abstract Cancer-associated fibroblasts (CAFs), the principal constituent of the heterogenous tumor microenvironment, have been shown to promote tumor progression; however, the underlying mechanism is still less clear. Here, we find that transgelin (TAGLN) protein levels increased in primary CAFs iso...

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Hlavní autoři: Chanjun Sun, Kaishang Zhang, Chen Ni, Jiajia Wan, Xixi Duan, Xiaohan Lou, Xiaohan Yao, Xiangnan Li, Ming Wang, Zhuoyu Gu, Pengyuan Yang, Zhenzhen Li, Zhihai Qin
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2023-03-01
Edice:Oncogenesis
On-line přístup:https://doi.org/10.1038/s41389-023-00463-5
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