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Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection

Abstract Background CTCF is a key insulator-binding protein, and mammalian genomes contain numerous CTCF sites, many of which are organized in tandem. Results Using CRISPR DNA-fragment editing, in conjunction with chromosome conformation capture, we find that CTCF sites, if located between enhancers...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Zhilian Jia, Jingwei Li, Xiao Ge, Yonghu Wu, Ya Guo, Qiang Wu
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2020-03-01
Rangatū:Genome Biology
Ngā marau:
CTCF
Insulator
Promoter/enhancer selection
3D genome
Gene regulation
Loop extrusion
Urunga tuihono:http://link.springer.com/article/10.1186/s13059-020-01984-7
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