Intestinal interleukin-22 enhances GLP-1 production via the STAT3 pathway to improve glucose homeostasis during high-fat diet induced obesity in a study with male mice

Abstract Metabolic disorders such as obesity and diabetes are influenced by glucagon-like peptide-1 (GLP-1), which regulates insulin secretion. Interleukin (IL)−22 maintains intestinal barrier function, yet its role in metabolic regulation remains unclear. Here, we show that intestinal IL-22 deficie...

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Principais autores:	Chae-Won Kim, Jae-Hee Ahn, Bo Ra Lee, Hong Min Kim, Youngjoo Han, Jae-Hyeon Jeong, Jaewon Cho, Hyunjin Jeong, Dae-Joon Kim, Seong-Eun Kim, Jeon-Kyung Kim, Yu-Bin Lee, Su Min Kim, Hye Hyun Yoo, Eun Hye Lee, Su Ryeon Seo, Kyung Bong Ha, Eun Soo Lee, Mi-Na Kweon, Hong Pyo Kim, Sun-Young Chang, Choon Hee Chung, Hyun-Jeong Ko
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2026-02-01
Serija:	Nature Communications
Online dostop:	https://doi.org/10.1038/s41467-026-69734-0
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