Carbonic Anhydrase IX-Targeted α-Radionuclide Therapy with 225Ac Inhibits Tumor Growth in a Renal Cell Carcinoma Model

In this study, we compared the tumor-targeting properties, therapeutic efficacy, and tolerability of the humanized anti-CAIX antibody (hG250) labeled with either the α-emitter actinium-225 (²²⁵Ac) or the β^--emitter lutetium-177 (¹⁷⁷Lu) in mice. BALB/c nude mice were...

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Principais autores:	Robin I. J. Merkx, Mark Rijpkema, Gerben M. Franssen, Annemarie Kip, Bart Smeets, Alfred Morgenstern, Frank Bruchertseifer, Eddie Yan, Michael P. Wheatcroft, Egbert Oosterwijk, Peter F. A. Mulders, Sandra Heskamp
格式:	Artigo
語言:	Inglês
出版:	MDPI AG 2022-05-01
叢編:	Pharmaceuticals
主題:	radioimmunotherapy RCC actinium-225 CAIX G250
在線閱讀:	https://www.mdpi.com/1424-8247/15/5/570
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