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Evaluating the causal effect of circulating proteome on the risk of inflammatory bowel disease-related traits using Mendelian randomization

ObjectiveThis study sought to identify circulating proteins causally linked to Inflammatory Bowel Disease (IBD) traits through a Mendelian Randomization (MR) analytical framework.MethodsUsing a large-scale, two-sample MR approach, we estimated the genetic links of numerous plasma proteins with IBD a...

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Principais autores: Beining Li, Ping Hu, Hongyan Liang, Xingliang Zhao, Aiting Zhang, Yingchong Xu, Bin Zhang, Jie Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-07-01
Serier:Frontiers in Immunology
Fag:
inflammatory bowel disease
mendelian randomization
protein
therapeutic target
singer cell
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1434369/full
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