Pulmonary artery pressure and iron deficiency in patients with upregulation of hypoxia sensing due to homozygous VHLR200W mutation (Chuvash polycythemia)

Background Patients with Chuvash polycythemia, (homozygosity for the R200W mutation in the von Hippel Lindau gene (VHL)), have elevated levels of hypoxia inducible factors HIF-1 and HIF-2, often become iron-deficient secondary to phlebotomy, and have elevated estimated pulmonary artery pressure by e...

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Главные авторы:	Craig A. Sable, Zakari Y. Aliyu, Niti Dham, Mehdi Nouraie, Vandana Sachdev, Stanislav Sidenko, Galina Y. Miasnikova, Lydia A. Polyakova, Adelina I. Sergueeva, Daniel J. Okhotin, Vladimir Bushuev, Alan T. Remaley, Xiaomei Niu, Oswaldo L. Castro, Mark T. Gladwin, Gregory J. Kato, Josef T. Prchal, Victor R. Gordeuk
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Ferrata Storti Foundation 2012-02-01
Серии:	Haematologica
Online-ссылка:	https://haematologica.org/article/view/6206
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