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Single-cell clonal tracking of persistent T-cells in allogeneic hematopoietic stem cell transplantation

The critical balance between intended and adverse effects in allogeneic hematopoietic stem cell transplantation (alloHSCT) depends on the fate of individual donor T-cells. To this end, we tracked αβT-cell clonotypes during stem cell mobilization treatment with granulocyte-colony stimulating factor (...

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Principais autores: Benedikt Obermayer, Luisa Keilholz, Thomas Conrad, Marco Frentsch, Igor-Wolfgang Blau, Lam Vuong, Stella Lesch, Kamran Movasshagi, Carola Tietze-Stolley, Lucie Loyal, Larissa Henze, Olaf Penack, Ulrik Stervbo, Nina Babel, Simon Haas, Dieter Beule, Lars Bullinger, Friedrich Wittenbecher, Il-Kang Na
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-02-01
Serier:Frontiers in Immunology
Fag:
scRNAseq
allogeneic HSCT
leukemia
transplantation
T-cells
clonal tracking
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1114368/full
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