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Development of Mitochondria-Targeted PARP Inhibitors

PARP inhibitors are a clinically validated class of anticancer therapeutics that exploit synthetic lethality to target homologous recombination-deficient tumors, such as those carrying BRCA1/2 mutations. Nevertheless, the rational design of mitochondria-targeted PARP inhibitors capable of selective...

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Principais autores: Pavels Dimitrijevs, Marina Makrecka-Kuka, Pavel Arsenyan
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-01-01
Serier:Biomolecules
Fag:
PARP inhibitors
olaparib
rucaparib
cardiolipin binding
mitochondrial targeting
phosphonium conjugates
Online adgang:https://www.mdpi.com/2218-273X/16/1/165
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