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Frequency of Gc-globin promoter –158 (C>T) XmnI polymorphism in patients with homozygous/compound heterozygous beta thalassaemia

BACKGROUND: Response to hydroxyurea therapy in homozygous or compound heterozygous beta thalassaemia (BT) has been reported as more favourable in the presence of XmnI polymorphism. The prevalence of XmnI polymorphism may vary with BT phenotypes and genotypes, and differs geographically in distributi...

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Principais autores: Nadir Ali, Muhammad Ayyub, Saleem Ahmed Khan, Suhaib Ahmed, Kazim Abbas, Hamid Saeed Malik, Sunila Tashfeen
Format: Artigo
Sprog:Inglês
Udgivet: Wolters Kluwer Medknow Publications 2015-01-01
Serier:Hematology/Oncology and Stem Cell Therapy
Fag:
beta thalassemia
hbf
hydroxyurea
xmn 1gγ
polymorphism
Online adgang:https://journals.lww.com/10.1016/j.hemonc.2014.12.004
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