Investigations towards the stereoselective organocatalyzed Michael addition of dimethyl malonate to a racemic nitroalkene: possible route to the 4-methylpregabalin core structure
Chiral derivatives of γ-aminobutyric acid are widely used as medicines and can be obtained by organocatalytic Michael additions. We show here the stereoselective synthesis of 4-methylpregabalin stereoisomers using a Michael addition of dimethyl malonate to a racemic nitroalkene. The key step of the...
সংরক্ষণ করুন:
| প্রধান লেখক: | , , |
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| বিন্যাস: | Artigo |
| ভাষা: | Inglês |
| প্রকাশিত: |
Beilstein-Institut
2018-03-01
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| মালা: | Beilstein Journal of Organic Chemistry |
| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://doi.org/10.3762/bjoc.14.42 |
| ট্যাগগুলো: |
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