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Advances in targeting histone deacetylase for treatment of solid tumors

Abstract Histone deacetylase (HDAC) serves as a critical molecular regulator in the pathobiology of various malignancies and have garnered attention as a viable target for therapeutic intervention. A variety of HDAC inhibitors (HDACis) have been developed to target HDACs. Many preclinical studies ha...

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Principais autores: Mu-Qi Shi, Ying Xu, Xin Fu, De-Si Pan, Xian-Ping Lu, Yi Xiao, Yi-Zhou Jiang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-05-01
coleção:Journal of Hematology & Oncology
Assuntos:
Histone deacetylase
Histone deacetylase inhibitor
Solid tumor
Combination therapy
Clinical administration
Acesso em linha:https://doi.org/10.1186/s13045-024-01551-8
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