Paired single-cell and spatial transcriptional profiling reveals a central osteopontin macrophage response mediating tuberculous granuloma formation

ABSTRACT Granulomas are classic manifestations of tuberculosis pathogenesis. They result from an ensemble of immune responses to Mycobacterium tuberculosis infection, but the identities, arrangement, cellular interactions, and regulation of the cells that comprise them have thus far been incompletel...

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Autores principales:	Charlie J. Pyle, Liuyang Wang, Rebecca W. Beerman, Vaibhav Jain, Henry K. E. Ohman, Brandon A. Thompson, Karen R. Abramson, Dennis C. Ko, Simon G. Gregory, Clare M. Smith, Jadee L. Neff, Rebecca J. Richardson, Jason E. Stout, David M. Tobin
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology 2025-09-01
Colección:	mBio
Materias:	tuberculosis granuloma Mycobacterium tuberculosis macrophage spatial transcriptomics osteopontin
Acceso en línea:	https://journals.asm.org/doi/10.1128/mbio.01559-25
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