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T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis

Summary: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Self-peptide-dependent autoproliferation (AP) of B and T cells is a key mechanism in MS. Here, we show that pro-inflammatory B-T cell-enriched cell clusters (BTECs) form during AP and mirror features of a...

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Principais autores: Ivan Jelcic, Reza Naghavian, Imran Fanaswala, Will Macnair, Cinzia Esposito, Daniela Calini, Yanan Han, Zoe Marti, Catarina Raposo, Jacobo Sarabia del Castillo, Pietro Oldrati, Daniel Erny, Veronika Kana, Galina Zheleznyakova, Faiez Al Nimer, Björn Tackenberg, Ina Reichen, Mohsen Khademi, Fredrik Piehl, Mark D. Robinson, Ilijas Jelcic, Mireia Sospedra, Lucas Pelkmans, Dheeraj Malhotra, Richard Reynolds, Maja Jagodic, Roland Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-03-01
coleção:Cell Reports Medicine
Assuntos:
multiple sclerosis
IFN-gamma
T cells
autoreactivity
T-bet+ B cells
CXCR3
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2666379125001004
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