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Structure, mechanism and clinical relevance of NRG1 fusions in cancer

Abstract NRG1 gene fusions have been identified in patients with various solid tumors. Such patients have aggressive tumors and respond poorly to currently available treatments. There are many gene partners described for NRG1 fusions, and the structures and roles of the chimeric proteins are not alw...

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Hauptverfasser: Clarisse Thiollier-Schmitt, Manon Barre, Marie Issenmann, Emeline Cros-Perrial, Michaël Duruisseaux, Lars Petter Jordheim
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2026-04-01
Schriftenreihe:Journal of Biomedical Science
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Online-Zugang:https://doi.org/10.1186/s12929-026-01242-1
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