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Melatonin protects against fluoride-induced developmental neurotoxicity by alleviating abnormal mitophagy and apoptosis via the PINK1/Parkin pathway

Fluoride induces developmental neurotoxicity, although the underlying mechanisms remain unclear. This study aimed to elucidate the roles of mitophagy and apoptosis mediated by the PTEN-induced kinase 1 (PINK1)/E3 ubiquitin-protein ligase Parkin (Parkin) pathway in fluoride-induced developmental neur...

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Autori principali: Chun Wang, Runjiang Ma, Wenqi Qin, Chulin Yan, Meng Zhang, Yajie Li, Yongkang Liang, Huayong Wu, Jingjing Zhang, Qiang Niu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2026-01-01
Serie:Ecotoxicology and Environmental Safety
Soggetti:
Fluoride
Melatonin
Mitophagy
PINK1/Parkin
Neurotoxicity
Accesso online:http://www.sciencedirect.com/science/article/pii/S0147651326001454
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