The role of ATP synthase subunit e (ATP5I) in mediating the metabolic and antiproliferative effects of metformin in cancer cells

Here, we identify the subunit e of F₁F₀-ATP synthase (ATP5I) as a target of metformin, a first-in-class antidiabetic biguanide. ATP5I maintains the stability of F₁F₀-ATP synthase dimers, which is crucial for shaping cristae morphology. We demonstrate that ATP5I interacts with a biguanide analogue in...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Guillaume Lefrançois, Emilie Lavallée, Marie-Camille Rowell, Véronique Bourdeau, Farzaneh Mohebali, Thierry Bertomeu, Ana Maria Duman, Maya Nikolova, Mike Tyers, Simon-Pierre Gravel, Andreea R Schmitzer, Gerardo Ferbeyre
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2026-05-01
coleção:	eLife
Assuntos:	F1ATPase mitochondria biguanides ATP5I NAD metabolism pancreatic cancer
Acesso em linha:	https://elifesciences.org/articles/102680
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!