Predicting the structural impact of human alternative splicing

Abstract Background Protein structure prediction with neural networks is a powerful new method for linking protein sequence, structure, and function, but structures have generally been predicted for only a single isoform of each gene, neglecting splice variants. To investigate the structural implica...

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Bibliografski detalji

Glavni autori:	Yuxuan Song, Chengxin Zhang, Gilbert S. Omenn, Matthew J. O’Meara, Joshua D. Welch
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2025-09-01
Serija:	Genome Biology
Teme:	Protein structure Alternative splicing AlphaFold2 Isoform function Single-Cell RNA-seq
Online pristup:	https://doi.org/10.1186/s13059-025-03744-x
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