Causal Relationships between Lipid-Lowering Drug Target and Aortic Disease and Calcific Aortic Valve Stenosis: A Two-Sample Mendelian Randomization

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), cholesteryl ester transfer protein (CETP) and apolipoprotein C3 (APOC3) are pivotal regulators of lipid metabolism, with licensed drugs targeting these genes. The use of lipid-...

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Asıl Yazarlar:	Liang Yang, Mingyuan Xu, Xixi Gao, Jingwen Liu, Dingkai Zhang, Zhaohua Zhang, Zhidong Ye, Jianyan Wen, Peng Liu
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	IMR Press 2024-08-01
Seri Bilgileri:	Reviews in Cardiovascular Medicine
Konular:	mendelian randomization lipid-lowering drug target aortic disease calcific aortic valve stenosis
Online Erişim:	https://www.imrpress.com/journal/RCM/25/8/10.31083/j.rcm2508292
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