Comparative analysis of dose-response variability and severity in STZ-induced diabetes: female vs. male NSG mice

Abstract This study evaluated the dose–response relationship of streptozotocin in female NSG mice to identify a dose that reliably induces diabetes mellitus while minimizing animal burden. Although streptozotocin is widely used to model insulin-dependent diabetes in rodents, sex-specific responses a...

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Prif Awduron:	Steven R. Talbot, Miriam Heider, Martin Wirth, Anne Jörns, Ortwin Naujok
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Nature Portfolio 2026-03-01
Cyfres:	Scientific Reports
Pynciau:	Female NSG mice Diabetes Streptozotocin Severity assessment RELSA
Mynediad Ar-lein:	https://doi.org/10.1038/s41598-026-42408-z
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!