Effect of endogenous hydrogen sulfide inhibition on structural and functional renal disturbances induced by gentamicin

Animal models of gentamicin nephrotoxicity present acute tubular necrosis associated with inflammation, which can contribute to intensify the renal damage. Hydrogen sulfide (H2S) is a signaling molecule involved in inflammation. We evaluated the effect of DL-propargylglycine (PAG), an inhibitor of e...

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Autori principali:	H.D.C. Francescato, J.R.A. Chierice, E.C.S. Marin, F.Q. Cunha, R.S. Costa, C.G.A. Silva, T.M. Coimbra
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Associação Brasileira de Divulgação Científica 2012-03-01
Serie:	Brazilian Journal of Medical and Biological Research
Soggetti:	Inflammation Gentamicin nephrotoxicity DL-propargylglycine Hydrogen sulfide Acute tubular necrosis
Accesso online:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000300010&lng=en&tlng=en
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