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The Tetraspanin CD81 Is a Host Factor for Chikungunya Virus Replication

ABSTRACT Chikungunya virus (CHIKV) is an arthritogenic reemerging virus replicating in plasma membrane-derived compartments termed “spherules.” Here, we identify the human transmembrane protein CD81 as host factor required for CHIKV replication. Ablation of CD81 results in decreased CHIKV permissive...

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Furkejuvvon:
Váldodahkkit: Lisa Lasswitz, Francisco J. Zapatero-Belinchón, Rebecca Moeller, Kirsten Hülskötter, Timothée Laurent, Lars-Anders Carlson, Christine Goffinet, Graham Simmons, Wolfgang Baumgärtner, Gisa Gerold
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: American Society for Microbiology 2022-06-01
Ráidu:mBio
Fáttát:
chikungunya virus
alphavirus
replication
CD81
tetraspanin
CHIKV
Liŋkkat:https://journals.asm.org/doi/10.1128/mbio.00731-22
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